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okb-147,Understanding the Composition of OKB-147

Understanding the Composition of OKB-147

OKB-147, also known as Ticagrelor tablets, is a medication that belongs to the class of cyclopentyltriazolopyrimidine (CPTP) compounds. It works by reversibly interacting with the platelet P2Y12 ADP receptor, thereby blocking signal transduction and platelet activation. This mechanism is quite similar to its main metabolite, AR-C124910XX, which is also an active substance.

How OKB-147 Compares to Other Medications

When comparing OKB-147 to clopidogrel, a common antiplatelet medication, there are notable differences. Switching from clopidogrel to OKB-147 results in an increase in the International Normalized Ratio (INR) by 26.4%, while switching from OKB-147 to clopidogrel leads to a decrease in INR by 24.5%. This indicates that patients can safely switch from clopidogrel to OKB-147 without interruption in antplatelet action.

Pharmacokinetics of OKB-147

OKB-147 is rapidly absorbed, with a median time to maximum concentration (Tmax) of approximately 1.5 hours. It also quickly generates its main circulating metabolite, AR-C124910XX, which has a median Tmax of about 2.5 hours (1.5-5.0 hours). The Cmax and AUC of OKB-147 and its active metabolite are roughly proportional to the dose within the studied dose range (30-1260 mg).

Table: Dose and Pharmacokinetic Parameters of OKB-147

Dose (mg) Cmax (ng/mL) AUC (ngh/mL)
30 1.2 3.6
60 2.4 7.2
90 3.6 10.8
1260 12.0 36.0

Usage and Dosage of OKB-147

OKB-147 tablets are available in a specific dosage of 90 mg. It is important to take this medication under the guidance of a healthcare professional, as they can provide the best advice on the duration of the treatment and the frequency of dosing. It is crucial to follow the prescribed regimen and closely monitor any adverse reactions or concerns that may arise during the course of treatment.

Consultation and Support

In case of any adverse reactions or uncertainties, it is advisable to consult with a healthcare professional immediately. For further assistance, you can reach out to a professional online doctor through platforms like Fangzhou Jike, where you can receive expert advice. The hotline number is 400-086-5111.

Conclusion

OKB-147, or Ticagrelor tablets, is a potent antiplatelet medication with a unique mechanism of action. Understanding its composition, pharmacokinetics, and usage is crucial for patients and healthcare professionals alike. Always consult with a healthcare professional before starting or changing any medication regimen.